article thumbnail

Abstract 37: The Brain Care Score and Neuroimaging Markers in Asymptomatic Individuals in the UK Biobank

Stroke Journal

The 21-point Brain Care Score (BCS) is a novel tool designed to motivate individuals and care providers to take action to reduce the risk of stroke and dementia by motivating lifestyle changes (Fig 1). FA/MD metrics were calculated as the average across 48 discrete brain regions.

article thumbnail

APOE4 & Cardiovascular Risk

Dr. Paddy Barrett

Being a carrier of the APOE4 gene variant is associated with higher rates of the most common type of dementia, late-onset dementia. Of those with late-onset dementia, up to 65% are carriers of the APOE4 gene variant 1. Of those with late-onset dementia, up to 65% are carriers of the APOE4 gene variant 1. What to do?

article thumbnail

Abstract WMP18: A Brain Care Score for Dementia and Stroke: Data From the UK Biobank Cohort

Stroke Journal

Background:The Brain Care Score (BCS) was developed through a modified Delphi process with practitioners and patients for implementation into primary care to stimulate behavioral changes and lifestyle choices to sustainably reduce the incidence of dementia and stroke (Fig 1).Methods:To 0.60], aged 50-59: HR: 0.68 [95%CI: 0.58-0.80],

article thumbnail

Abstract WMP19: A Brain Care Score for Risk of Late-Life Depression: Data From the UK Biobank Cohort

Stroke Journal

Introduction:The 21-point Brain Care Score (BCS), developed via a modified Delphi process with practitioners and patients, is a novel instrument designed to motivate behavioral and lifestyle changes, ultimately aiming to decrease incidence of dementia and stroke (Fig 1). 0.74) among those aged 50-59; and 28% (HR: 0.72, 95% CI: 0.65-0.79)

article thumbnail

The legal case – naming a few names

Dr. Malcolm Kendrick

Assessing the potential for SenseCam to fight the current global health crises of increasing obesity and physical inactivity (2010-2013) Microsoft: £69K ATLAS trial of tamoxifen duration (1997-2018) AstraZeneca: £1.0M Elinogrel feasibility trial (2010-2011) Novartis: £500K EMPA-KIDNEY (2017-ongoing) Boehringer Ingelheim: £106.3M

article thumbnail

Abstract TMP105: Development and Validation of a Risk Prediction Model for Ischemic Stroke Among Individuals Newly Diagnosed With Cancer

Stroke Journal

Patients were randomly selected for model derivation (60%) or validation (40%). The final model predicting stroke within 1 year following cancer diagnosis was derived using multivariable Fine-Gray regression with candidate predictors selected via backward elimination. The overall rate of stroke per 1000 person-years was 6.7 (6.4 6.4 - 6.9)

Cancer 40
article thumbnail

Emergency Department Syncope Workup: After H and P, ECG is the Only Test Required for Every Patient.

Dr. Smith's ECG Blog

in 2010 EM Clinics of North America (full text link) For an Exhaustive Review of Syncope and its full management outside the ED environment, go to the 2009 European Society of Cardiology Guidelines (full text pdf). J Am Coll Cardiol, 2010; 55:713-721, doi:10.1016/j.jacc.2009.09.049