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Cedars-Sinai investigators are using AI to analyze images from a common heart test to identify signs of valve disease. Photo: Getty. tim.hodson Wed, 04/16/2025 - 14:19 April 16, 2025 An artificial intelligence (AI) program trained to review images from a common medical test can detect early signs of tricuspid heart valve disease and may help doctors diagnose and treat patients sooner, according to research from the Smidt Heart Institute at Cedars-Sinai.
ObjectiveAortic dissection (AD) is a life-threatening cardiovascular emergency. Delayed diagnosis frequently leads to treatment delays, elevated mortality, and complications. This study investigates the factors contributing to the misdiagnosis of AD and proposes strategies for improving its early diagnosis.MethodsA retrospective analysis of 801 patients with AD identified 219 cases for inclusion, which were split into a training set (131 cases) and a validation set (88 cases).
Circulation, Ahead of Print. The Physical Activity Guidelines for Americans supports sitting less and moving more. Growing evidence suggests that a waking behavior profile with less sedentary behavior and more light-intensity physical activity is associated with more favorable cardiovascular health. Remarkably, little is known about how these behaviors relate to cardiovascular health during pregnancy.
More than heart disease or cancer, dementia is the primary concern for many of the patients I see. Heart disease and cancer attack your body, but dementia attacks your mind and identity. It strips away the fabric of who a person is. That is why I believe people fear dementia so much. Thankfully, 45% of all dementia is preventable 1. Many factors make up that 45%, but one factor seems to impact the risk of dementia the most.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Nature Reviews Cardiology, Published online: 14 April 2025; doi:10.1038/s41569-025-01150-1 In this Review, Liu, Yang and He explore the diverse mechanisms by which various post-translational protein acylations, and the dynamic interactions between them, contribute to cardiac hypertrophy. The authors also discuss the therapeutic potential of targeting acylations to modulate their effects on chromatin architecture, enzyme activity and metabolic pathways.
Background Kuwait, one of the world’s hottest countries, faces increasing temperatures due to climate change. With a large migrant population predominantly employed in physically demanding jobs, the exact effects and burdens of temperature exposure on cardiovascular risk among this population remain unknown. This study aimed to investigate the relationship between temperature and myocardial infarction (MI) risk among migrants in Kuwait.
Completing its pharma comeback story, Verve Therapeutics announced successful results from the Heart-2 Phase 1b Clinical Trial of its in-vivo base editing drug, VERVE-102, that targets the PCSK9 gene for reducing LDL-C. PCSK9 is a molecule that breaks down LDL receptors, so drugs that inhibit it force the bodys LDL receptors to work harder, which reduces LDL-C more efficiently.
Completing its pharma comeback story, Verve Therapeutics announced successful results from the Heart-2 Phase 1b Clinical Trial of its in-vivo base editing drug, VERVE-102, that targets the PCSK9 gene for reducing LDL-C. PCSK9 is a molecule that breaks down LDL receptors, so drugs that inhibit it force the bodys LDL receptors to work harder, which reduces LDL-C more efficiently.
tim.hodson Tue, 04/15/2025 - 15:54 April 15, 2025 DESKirecently announced FDA clearance for HeartFocus , its AI-enabled heart exam software that empowers any healthcare professional, including novices, to perform clinical-quality heart scans from any compatible device after just a few hours of training. The FDA also approved DESKis Predetermined Change Control Plan (PCCP) for HeartFocus growth opportunities.
Experts discuss the challenges of identifying and diagnosing hypercortisolism, the reasons behind its often-delayed diagnosis, the impact of a wide spectrum of clinical signs and symptoms on clinicians ability to diagnose the condition, and recent data on the prevalence of hypercortisolism in at-risk populations, including those with difficult-to-control diabetes, hypertension, and cardiovascular disease.
Cardiovascular disease (CVD) remains a global health burden despite advances in prevention and treatment. Conventional biomarkers, while effective for a number of patient groups, fail to provide personalized diagnosis and prognosis, necessitating the exploration of novel markers. Advancements in sequencing technology have unveiled the role of cell-free DNA (cfDNA) as a reservoir of genetic information from all cells within the body, and associations between elevated cfDNA levels and CVD risk fac
Background Heart failure (HF) guidelines recommend routine testing for iron deficiency (ID) and, for those with ID, intravenous iron if the left ventricular ejection fraction is <50%. Guideline adherence to these recommendations by cardiologists in China is unknown. Methods and results An independent academic web-based survey was designed and distributed via social networks to cardiologists across China.
Dr. Prateek Bhatnagar, the best cardiac surgeon in India, operated a 68-year-old gentleman from Bengal, who had been refused coronary bypass surgery by leading cardiac centers across India, due to the high-risk nature of his condition. The patient had a critically low pumping of heart (left ventricular ejection fraction) of just 22%, indicating severely compromised heart function.
Statement Highlights: While the strongest evidence exists that getting sufficient sleep (duration of sleep) is important for overall health , other components of sleep health, such as consistent bedtime, uninterrupted sleep, daytime functioning and.
New research suggests increasing the ratio of dietary potassium to sodium intake may be more effective for lowering blood pressure than simply reducing sodium intake.
Chronic heart failure (CHF) combined with depression represents a significant clinical challenge due to the mutual exacerbation of physical and psychological symptoms. This study investigated the therapeutic effects of Zhigancao decoction, a traditional Chinese medicine, in combination with conventional Western treatments in patients with CHF and depression.
Since the first implementation in 2002 by Alain Cribier, transcatheter aortic valve replacement (TAVR) has become a standard procedure for high-risk and elderly patients with severe aortic valve stenosis. Recently, the use of TAVR has expanded to relatively younger patients with low to moderate surgical risk. Infective endocarditis (IE) after TAVR, first reported in medical literature in 2010, is a relatively new and extremely concerning complication. 1 Its incidence, reported as 1.1% per person
(MedPage Today) -- BOSTON -- After living kidney donation, projection of renal function may vary by gender, a retrospective cohort study of 174,311 living kidney donors suggested. Over a median 6.7 months, the incidence rate of worsening post.
Hypertension, Ahead of Print. BACKGROUND:Aberrant BMPR2 (bone morphogenetic protein receptor 2) signaling is associated with the pathogenesis of pulmonary hypertension. SMAD4 is an essential downstream effector of BMPR2 signaling, but whether and how it participates in pulmonary hypertension are unclear.METHODS:Globally and vascular cell-specifically inducible knockout mouse models were used to examine the role of SMAD4 deficiency in differential cell compartments in the development of pulmonary
BackgroundHeart failure (HF) is a multifaceted clinical condition, and our comprehension of its genetic pathogenesis continues to be significantly limited. Consequently, identifying specific genes for HF at the transcriptomic level may enhance early detection and allow for more targeted therapies for these individuals.MethodsHF datasets were acquired from the Gene Expression Omnibus (GEO) database (GSE57338), and through the application of bioinformatics and machine-learning algorithms.
‘Real knowledge is to know the extent of one’s ignorance ’ Confucius This editorial refers to ‘Gaps in knowledge and management of iron deficiency in heart failure: a nationwide survey of cardiologists in China’, by Su et al. 1 Over the last 25 years, an accumulation of data has highlighted the prevalence of iron deficiency and the value of its correction in patients with heart failure and reduced (HFrEF) or mildly reduced ejection fraction (HFmrEF).
(MedPage Today) -- People that required emergency department (ED) or acute hospital care for cannabis use may have an increased risk of a subsequent dementia diagnosis, a retrospective matched cohort study of 6 million people in Canada suggested.
ABSTRACT Introduction Pulsed Field Cryoablation (PFCA) is a dual-energy cardiac ablation modality consisting of short-duration ultra-low temperature cryoablation (ULTC) followed immediately by pulsed field ablation (PFA) delivered from the same catheter. It is hypothesized that PFCA may improve contact stability during PFA, while maintaining lesion depth and effectiveness of ULTC.
ObjectiveTo compare the image quality, radiation dose, and examination time between non-electrocardiogram (ECG)-gated coronary CT angiography (ECG-less CCTA) and conventional ECG-gated CCTA using wide-detector CT, and validate its clinical applicability.MethodsIn this prospective study, 109 patients with suspected coronary artery disease were divided into ECG-less (Group A, n=59) and ECG-gated (Group B, n=50) groups.
Researchers have developed an AI tool that creates synthetic yet medically accurate models of fibrotic heart tissue (heart scarring), aiding treatment planning for atrial fibrillation (AF) patients. The study could lead to more personalized care for patients affected by this common heart rhythm disorder.
(MedPage Today) -- The link between narcolepsy and cardiovascular disease (CVD) was strengthened by new evidence that the relationship applied to subclinical disease and was apparent early in life, based on a retrospective cohort study. Across.
ABSTRACT Introduction The role of corticosteroids in the management of ventricular tachyarrhythmia (VA) in cardiac sarcoidosis (CS) remains controversial. This study assessed the effect of early steroid initiation on VA recurrence rates in patients with CS and evaluated VA frequency before and after steroid therapy. Methods From a registry of 137 patients with CS with arrhythmias, those with VA and more than 60 days of follow-up were included.
Unlike mammals, zebrafish can regenerate their heart after cardiac insult. There are several ways to perform cardiac injury in zebrafish, but cryoinjury most closely resembles human myocardial infarction (MI). Studies demonstrated that macrophages are essential cells from the beginning to later stages of cardiac injury throughout the regenerative process in zebrafish.
People with a certain heart valve abnormality are at increased risk of severe heart rhythm disorders, even after successful valve surgery. The condition is more common in women and younger patients with valve disorder and can, in the worst case, lead to sudden cardiac arrest.
Circulation, Volume 151, Issue 15 , Page 1111-1125, April 15, 2025. Heart failure is a growing health-care concern affecting tens of millions of individuals globally. Although traditional therapeutic strategies have focused on reducing the risk for hospitalization and mortality, the importance of patient-reported outcomes (PROs) in patients with heart failure is increasingly being recognized.
Background and AimHypertension (HTN) is a widespread global health challenge, and its increasing prevalence is attributed to individual and environmental risk factors. Persistent organic pollutants (POPs), especially polychlorinated biphenyls (PCBs), contribute to cardiovascular risk by accumulating in fatty tissues, which leads to oxidative stress and vascular inflammation.
(MedPage Today) -- Rheumatoid arthritis (RA) patients face very different risks for cardiovascular disease and events depending on their body mass index (BMI), use of biologic drugs for RA, and, crucially, whether they carry anti-citrullinated.
Electronic health interventions improved medication adherence in kidney transplant recipients, with potential implications for improving patient outcomes.
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