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Spatiotemporal transcriptomic mapping of regenerative inflammation in skeletal muscle reveals a dynamic multilayered tissue architecture

Journal of Clinical Investigation - Cardiology

Tissue regeneration is orchestrated by macrophages that clear damaged cells and promote regenerative inflammation. How macrophages spatially adapt and diversify their functions to support the architectural requirements of actively regenerating tissue remains unknown. In this study, we reconstructed the dynamic trajectories of myeloid cells isolated from acutely injured and early stage dystrophic muscles.

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Type 2 Diabetes Diagnoses Emerge in Teens Months After COVID

Med Page Today

(MedPage Today) -- Children and teens had an increased risk of being diagnosed with type 2 diabetes after COVID-19 infection, a retrospective cohort study of over 600,000 youth suggested. Adolescents 10 to 19 years old had a 55% higher risk for.

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ECG Blog #451 — Premature Closure.

Ken Grauer, MD

I was sent the ECG shown in Figure-1 — told only that the patient was a middle-aged man with septicemia. QUESTIONS: Is this rhythm too fast to be sinus tachycardia? Are flutter waves hidden within the QRS and T waves? Are we seeing the retrograde P waves of AVNRT? Is this ATach ( A trial T achycardia )? Figure-1: The initial ECG in today's case. MY Thoughts on Today’s CASE: In my opinion — none of the above answers are optimal to describe the rhythm in Figure-1.

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Heart failure, atrial fibrillation & coronary heart disease linked to cognitive impairment

American Heart News - Heart News

Statement Highlights: Previous studies have found that 14-81% of patients with heart failure experience some degree of cognitive impairment affecting language, memory or executive function. Evidence also indicates that people with atrial fibrillation.

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Women with Little to No Migraine Disability Had a Lower Quality of Life Than Men

HCPLive

A study found that migraine-related disability worsens health-related quality of life, with gender-specific differences, particularly affecting women with mild disability.

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Cath Lab occupied. Which patient should go now (or does only one need it? Or neither?)

Dr. Smith's ECG Blog

This was sent to me by an undergraduate name Hans Helseth, who is an EKG tech, but who is an expert OMI ECG reader. He wrote most of it and I (Smith) edited. A prehospital “STEMI” activation was called on a 75 year old male ( Patient 1 ) with a history of hyperlipidemia and LAD and Cx OMI with stent placement. He arrived to the ED by helicopter at 1507, about three hours after the start of his chest pain while chopping wood around noon.

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Loneliness Tied to Alzheimer's and Dementia Risk

Med Page Today

(MedPage Today) -- Loneliness increased the risk for all-cause dementia, a meta-analysis that included more than 600,000 people showed. Feeling lonely was tied to a 31% higher risk of overall dementia (HR 1.306, 95% CI 1.197-1.426), according.

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Six proteins implicated in early-onset preeclampsia

Science Daily - Heart Disease

Preeclampsia is a life-threatening pregnancy complication marked by persistent high blood pressure that is even more serious when it occurs early in the first trimester. The exact cause of early-onset preeclampsia is unknown, and it is difficult to predict, prevent and diagnose. Now researchers report on six proteins that could be used as targets to diagnose and treat the condition.

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Nanoscope Signals BLA Submission for MCO-010 for Retinitis Pigmentosa

HCPLive

Based on the regulatory feedback provided by the FDA, Nanoscope announced plans to initiate Biologics License Application submission in Q1 2025.

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1st COVID wave infections tied to stroke, heart attack risks

Becker's Hospital Review - Cardiology

People who had a confirmed case of COVID-19 during the pandemic's first wave have twice the risk of heart attack, stroke and death compared to those who were never infected, according to research funded by the National Institutes of Health.

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An elderly male with acute altered mental status and huge ST Elevation

Dr. Smith's ECG Blog

Written by Bobby Nicholson What do you think of this “STEMI”? A man in his 90s with a history of HTN, CKD, COPD, and OSA presented to the emergency department after being found unresponsive at home. With EMS, patient had a GCS of 3 and was saturating 60% on room air. He improved to 100% with the addition of non-rebreather, however remained altered and was intubated by EMS with ketamine and succinylcholine.

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New laser light diagnostic tool quickly detects earliest sign of heart attack

Medical Xpress - Cardiology

With heart attacks, every second counts. A new blood test diagnoses them in minutes rather than hours and could be adapted as a tool for first responders and people at home.

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Transcript splicing optimizes the thymic self-antigen repertoire to suppress autoimmunity

Journal of Clinical Investigation - Cardiology

Immunological self-tolerance is established in the thymus by the expression of virtually all self-antigens, including tissue-restricted antigens (TRAs) and cell-type–restricted antigens (CRAs). Despite a wealth of knowledge about the transcriptional regulation of TRA genes, posttranscriptional regulation remains poorly understood. Here, we show that protein arginine methylation plays an essential role in central immune tolerance by maximizing the self-antigen repertoire in medullary thymic epith

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First Melanoma History is Risk Factor for Subsequent Diagnoses Regardless of Race

HCPLive

This analysis indicates that patients with a history of a first melanoma are at risk for subsequent development of melanoma regardless of their race or their ethnicity.

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Millions of Aging Americans Are Facing Dementia by Themselves

Med Page Today

(MedPage Today) -- Sociologist Elena Portacolone, PhD, was taken aback. Many of the older adults in San Francisco she visited at home for a research project were confused when she came to the door. They'd forgotten the appointment or couldn't remember.

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If you were this patient, would you prefer to be managed with the Queen of Hearts?

Dr. Smith's ECG Blog

Written by Pendell Meyers A man in his early sixties with no significant medical history (including a "negative cardiac workup a few years ago" for unclear indication) called 911 for acute chest pain constantly for the past 5 hours. EMS arrived and recorded vital signs within normal limits and the following ECG during active pain: EMS1 @ 0157: What do you think?

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What's missing in cardiology conversations

Becker's Hospital Review - Cardiology

From preparing for the effects of AI to bracing for the "silver tsunami," here is what cardiology leaders who shared their insights with Becker's said should be prominent topics of conversation in the industry.

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Cassling Partner Echo IQ Secures FDA Clearance for EchoSolv AS

Cassling

510(k) clearance secured from FDA allows for EIQ’s AI-enabled solution, EchoSolv AS, to be marketed and sold in the USA Clearance marks a major milestone and will allow for rapid commercial scale-up EIQ is in advanced discussions with a range of US healthcare providers around the potential uptake of EchoSolv AS Working alongside US consultancy to obtain reimbursement codes for the use of EchoSolv AS under insurance to scale up following FDA clearance Sydney: AI and Medical Technology company Ech

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Online Tool Developed to Improve Diagnostic Skills of Non-Dermatologists for Psoriasis

HCPLive

This online diagnostic tool’s implementation among study participants led to increased confidence in making diagnoses of chronic plaque psoriasis.

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Do patients have a “happiness set point?”

Heart Sisters

The best predictor of how happy you'll be several months after a major life event (positive or negative) might be how happy you were before it happened.

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Two patients with chest pain and RBBB: do either have occlusion MI?

Dr. Smith's ECG Blog

Written by Jesse McLaren Two patients in their 70s presented to the ED with chest pain and RBBB. Do either, both, or neither have occlusion MI? Patient 1 : a 75 year old called paramedics with one day of left shoulder pain which migrated to the central chest, which was worse with deep breaths. Past medical history included RBBB without other cardiac history, but old ECG was not available.

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The heart health, dementia link: 7 things to know

Becker's Hospital Review - Cardiology

Addressing heart health earlier in life may affect and even deter dementia risk later in life, according to research published by The American Heart Association Oct. 10 in Stroke.

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Highest Paid Medical Specialties in 2024

Med Page Today

(MedPage Today) -- While it's true that becoming a doctor means a guaranteed six-figure salary, these salaries vary dramatically between specialties. The good news is in 2024, the Physician Compensation Report from Doximity listed 12 medical.

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Short-Term Surge in Air Pollution May Trigger Schizophrenia Episodes

HCPLive

A short-term rise in air pollution levels between neighboring days was significantly linked to an increased risk of schizophrenia hospitalizations in China.

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Cardiac Arrhythmias and Autonomic Dysfunction Associated With COVID-19: A Scientific Statement From the American Heart Association

Circulation

Circulation, Ahead of Print. Cardiac arrhythmias are commonly noted in patients during infections with and recovery from COVID-19. Arrhythmic manifestations span the spectrum of innocuous and benign to life-threatening and deadly. Various pathophysiological mechanisms have been proposed. Debate continues on the impact of incident and exacerbated arrhythmias on the acute and chronic (recovery) phase of the illness.

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Will Humans Live to 150? Not in Our Lifetime

Physiologically Speaking

If you could live to be 150 years old, would you? One’s answer to this question inevitably hinges on a few things: Whether they’ll arrive there in good health and whether they’ll get to enjoy longevity with friends and family whom they love. What’s the allure of immorality spent in isolation and despair? I, for one, would gladly jump at any opportunity that gave me a chance of nearly doubling the average human lifespan.

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Hospitals with highest, lowest 30-day mortality rates for heart attack patients

Becker's Hospital Review - Cardiology

New York City-based NYU Langone hospital had the lowest 30-day mortality rate for heart attack patients in the U.S. between July 1, 2020 and June 30, 2023, according to CMS data released July 31.

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Do Lipid Values in Adolescence Improve CVD Risk Prediction?

Med Page Today

(MedPage Today) -- Non-laboratory-based risk factors and lipids measured in adolescence independently predicted adult cardiovascular events, according to data from seven longitudinal cohort studies. In a multivariable model using non-laboratory.

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Jonathan Meyer, MD: Cognitive Gains, Dopamine-Free Schizophrenia Treatment with Xanomeline Trospium Chloride

HCPLive

Xanomeline trospium chloride offers a new pathway in schizophrenia treatment, improving cognitive symptoms without D2 receptor-related side effects like tardive dyskinesia.

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Cannabis use disorder: from neurobiology to treatment

Journal of Clinical Investigation - Cardiology

Cannabis has been legalized for medical and recreational purposes in multiple countries. A large number of people are using cannabis and some will develop cannabis use disorder (CUD). There is a growing recognition that CUD requires specific interventions. This Review will cover this topic from a variety of perspectives, with a particular emphasis on neurobiological findings and innovative treatment approaches that are being pursued.

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Standing more may not reduce cardiovascular disease risk, could increase circulatory disease, research finds

Science Daily - Heart Disease

New research has shown that over the long-term, standing more compared with sitting does not improve cardiovascular health (coronary heart disease, stroke and heart failure), and could increase the risk of circulatory issues related to standing, such as varicose veins and deep vein thrombosis.

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Initial prescriptions of sedatives among older stroke survivors may include too many pills

American Heart News - Heart News

Research Highlights: Within 90 days after having an ischemic (clot-caused) stroke, about 5% of stroke survivors ages 65 and older were prescribed benzodiazepines (depressants that relieve anxiety, muscle spasms, produce sedation and reduce seizures).

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Hot news flash: Menopause can impact a woman's heart health

Medical Xpress - Cardiology

The risk of heart disease increases with age for most people, however, for women that may be even more true. The menopause transition, those years leading up to and through menopause, is a time of increasing heart disease risk, according to an American Heart Association scientific statement published in the flagship journal Circulation in 2020.

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FASCINATE-2: Denifanstat Improves Disease Activity, MASH Resolution, Fibrosis

HCPLive

New phase 2b data highlight denifanstat’s impact on histological features of MASH, meeting both fibrosis improvement and MASH resolution primary endpoints.

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Cardiac Contributions to Brain Health: A Scientific Statement From the American Heart Association

Stroke Journal

Stroke, Ahead of Print. The burden of neurologic diseases, including stroke and dementia, is expected to grow substantially in the coming decades. Thus, achieving optimal brain health has been identified as a public health priority and a major challenge. Cardiovascular diseases are the leading cause of death and disability in the United States and around the world.

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Invention quickly detects earliest sign of heart attack

Science Daily - Heart Disease

With heart attacks, every second counts. A new blood test diagnoses them in minutes rather than hours and could be adapted as a tool for first responders and people at home.

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La insuficiencia cardíaca, la fibrilación auricular y la enfermedad coronaria están relacionadas con el deterioro cognitivo

American Heart News - Heart News

Aspectos destacados de la declaración: En estudios anteriores se ha descubierto que entre el 14 y el 81% de los pacientes con insuficiencia cardíaca presentan algún grado de deterioro cognitivo que afecta el lenguaje, la memoria o la función.

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